Research

The Hsueh lab is studying the molecular and cell biology of the ovary using genomic and bioinformatic approaches:
 
PubMed search of our publications
In Vitro Activation (IVA) and Hippo signaling-Clinical Application
In Vitro Activation (IVA) of dormant follicles Although multiple follicles are present in mammalian ovaries, most of them remain dormant for years or decades. Short-term in vitro activation (IVA) of dormant ovarian follicles following stimulation of the PI3K-Akt pathway allows the generation of a large supply of mature female germ cells for infertility treatment in the future.
Intraovarian control of early folliculogenesis Preantral follicles are under stringent regulation by FSH and local intra-ovarian factors, understanding of these mechanisms provides the possibility to develop new therapeutic approaches.
Ovulation The mid-cycle surge of LH induces multiple ovarian genes essential for follicle rupture, cumulus expansion, luteinization, as well as oocyte maturation and early embryo development. We are investigating paracrine mechanisms underlying the ovulatory process.
Polypeptide hormones activating GPCRs Pairing of polypeptide hormones with their cognate G protein-coupled receptors (GPCRs).
Gonadotropin receptors structure-function relationship of gonadotropin receptors and other LGRs (leucin-rich repeat, G-protein coupled receptors)
Follicle development hormonal basis of follicle recruitment and differentiation, oocyte/granulosa cell communication
Genomics Play video Play video: Evolutionary Genomics (Win Media player, 30 min 43Mb) Get Win Media Player

identification of novel endocrine genes using computational tools and DNA microarrays
Bioinformatics Using bioinformatic approaches, we established several databases (see more in the linked page..).
Gonadal cell apoptosis molecular basis of follicular atresia, characterization of Bcl-2 family proteins 
   

 

This page was last modified on 27 Jan 2015.